AHCC is a Powerful Aid in Fighting Viruses and Infections #3

Another study looked at the effect of AHCC supplementation against infection with H5N1 avian influenza virus (bird flu).

 

Mice were infected with 100 times the 50 percent lethal dose of the H5N1 influenza virus. The control mice that did not receive AHCC demonstrated 100 percent mortality at 12 days post-infection. In contrast, the group that was fed AHCC prior to infection demonstrated a 30 percent survival through 28 days post-infection. In a second study utilizing the same protocol, the effects of AHCC supplementation alone were compared to H5N1 vaccination (the flu vaccine) alone as well as the combination of AHCC supplementation and the flu vaccine administered together. Vaccination alone resulted in approximately 80 percent survival, while AHCC supplementation combined with vaccination resulted in 100 percent survival. This data suggests while AHCC supplementation alone offers some protection against mortality associated with highly-virulent avian influenza virus infection in mice, supplementation with AHCC may be even more effective as an addition to the flu vaccine.

 

In another study, mice infected with a lethal dose of West Nile virus showed that mice supplemented with AHCC prior to the infection exhibited an increase in survival and a decrease in virus load in the blood at four days post-infection.

 

Looking at “opportunistic” or hospital-acquired infections, the effects of AHCC supplementation on the resistance to Klebsiella pneumoniae (principally associated with bacterial pneumonia and urinary tract infections) was studied in both infected and stressinduced mice. Again, the AHCC-supplemented mice demonstrated increased survival, increased mean time until death, decreased susceptibility to infection and increased bacterial clearance from the blood. Studies on other types of opportunistic infections including methicillinresistant Staphylococcus aureus (MRSA), Candida albicans and Pseudomonas aeruginosa provided similar results: AHCC overwhelmingly increased survival in immune compromised mice in response to infectious challenge.

 

Given the abundance of preliminary positive results across different infections, AHCC supplementation demonstrates valuable and clinically-relevant potential as an immune-enhancing compound. Furthermore, since AHCC supplementation was shown in one study to be even more beneficial when used in conjunction with the flu vaccine, studies are underway to further evaluate the use of AHCC as a preventive during flu season. Finally, AHCC boasts a strong safety profile supported by a Phase I study conducted at Harvard, a 20-year history of use in Japan, its adoption by over 700 clinics and use by an estimated 70,000 people worldwide (including 20,000 in the U.S.). Thus, there is a strong case to be made for adding AHCC to a daily supplement regimen to support the body’s immune system, not only during the apparent times of increased infectious threat such as the flu season, but also all year long.

 

Dr. Fred Pescatore, M.D., MPH, is the Medical Director of Partners in Integrative Medicine and an author of several best-selling books on health and nutrition.

Barry Ritz, Ph.D. is the Professor of Bioscience and Biotechnology at Drexel University, whose paper on AHCC and influenza was recently published in the Journal of Nutrition.

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